Covid-19 vaccine research bottlenecks

Most articles report on only a few companies doing vaccine research. This is the most comprehensive article I’ve found. https://www.nature.com/articles/d41573-020-00073-5  

“Although a number of large multinational vaccine developers (such as Janssen, Sanofi, Pfizer and GlaxoSmithKline) have engaged in COVID-19 vaccine development, many of the lead developers are small and/or inexperienced in large-scale vaccine manufacture. So, it will be important to ensure coordination of vaccine manufacturing and supply capability and capacity to meet demand.”

This last point may be a major bottleneck. If there is no deal and close co-ordination between a small Biotech and a Big Pharma who can manufacture the drug, valuable time will be lost.Big Pharma has never put public health interests before its own licensing and patent protection. 
https://www.theguardian.com/commentisfree/2020/apr/15/coronavirus-treatment-drug-companies

Estimates for development of a virus are widely said to be 12-18 months. 
https://www.theguardian.com/world/2020/apr/19/coronavirus-vaccine-when-will-we-have-one

If this is the time to get a lab proven result, the drug still needs FDA approval (even fast track takes some time), then manufacturing which needs time to source the ingredients, set up the manufacturing infrastructure and then scale it up to produce large volume. All of these steps take time, so the total time could be quite a lot longer than 12-18 months.

In addition, distribution will take time. If a target is 50% of the population to reach a safe level (somewhat less than herd immunity threshold), that’s about 4 billion people. Assuming the drug companies manipulate the supplies behind the scenes and distribute most to Europe and North America first, that’s still 50% of 1 billion.

Here’s a terrific article with interactive timelines showing the potential delays at each step until distribution. https://www.nytimes.com/interactive/2020/04/30/opinion/coronavirus-covid-vaccine.html

Most years, I have to wait for the regular flu vaccine because of distribution delays. Is anybody betting they will be able to get a vaccination in 18 months as predicted?

Author: Ernie Dainow

I was fascinated with mathematics at an early age. In university I became more interested in how people think and began graduate work in psychology. The possibilities of using computers to try to understand the brain by simulating learning and thinking became an exciting idea and I completed a Master’s degree in Artificial Intelligence in Computer Science. My interest in doing research shifted to an interest in building systems. I worked for 40+ years in the computer field, on large mainframe computers, then personal computers, doing software development for academic and scientific research, business and financial applications, data networks, hardware products and the Internet. After I retired I began writing to help people understand computers, software, smartphones and the Internet. You can download my free books from Apple iBooks, Google Play Books and from https://www.smashwords.com/profile/view/edainow

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